With 16 U.S. states banning the sale of household dishwashing detergents with salt content exceeding 0.5% (traditional inorganic salt builders cause eutrophication of water bodies), global daily chemical enterprises are facing pressure for raw material replacement. As a chemical raw material supplier, BASF needs to develop alternative formulations with both cleaning performance and environmental attributes. The company’s Care Chemicals division set up an R&D team targeting green ingredients to replace traditional polycarbonate powder. Using JMP Statistical Discovery Software, the team conducted multi-factor experimental design to evaluate the synergistic effects of seven components including chelating agents, polymers, and builders. Through three-level mixture design, the team simulated actual cleaning scenarios (such as removing egg, cereal, and gravy residues from tableware), conducted performance tests and data modeling on different formula combinations. This not only shortened the experimental design time by 75% but also accurately identified the optimal formula centered on Trilon® M chelating agent. The formula contains no traditional high-salt components, has cleaning effect equivalent to salt-containing products, and is the first product of its kind certified by the U.S. EPA’s Design for the Environment (DfE) program. It has been successfully supplied to many consumer goods and commercial cleaning companies worldwide, helping customers meet environmental compliance requirements while expanding BASF’s market share of green raw materials.